Overview

Greene Tweed is an industry expert in high-performance seals, thermoplastics, and composites for life sciences applications. With a commitment to quality and innovation, we have developed successful outcomes for the most challenging applications in pharmaceutical manufacturing, medical devices, analytical, and food and beverage.

Greene Tweed offers best-in-class materials for the life sciences industry, including Chemraz®, Orthtek®, and Avalon®. In addition to our long-standing material innovation, you also get application design expertise and validated manufacturing processes – all from the same supplier.

We are dedicated to quality, with teams that work with you to provide the documentation, testing, and facility audits to support your regulated application.

Working with Greene Tweed is easy, and we are always looking to solve new customer challenges. Contact our team to learn how we can help.

Life Sciences Applications

Applications

Greene Tweed offers solutions for the full spectrum of life science applications, including pharma, medical devices and analytical Instrumentation.

Pharma

Chemraz® SD517

Chemraz® SD625

Pharma API manufacturing and drug formulation equipment need to be highly pure and stable to a wide array of solvents and temperatures. Flexible seals such as o-rings, gaskets, and diaphragms are the weakest point of many systems, and their failure inevitably results in adulterated batches followed by extensive non-conformance investigations. Designing separate reactors for each solvent system is cumbersome and requires excessive capital.

To solve these challenges, Greene Tweed offers Chemraz® SD517 and Chemraz® SD625, high-performance PTFE-like sealing materials that offer unparalleled stability and lifetime service to nearly all pharma manufacturing and processing conditions.

Greene Tweed Chemraz® seals are available in standard and custom shapes, or as a sheet. All Chemraz® materials are available as o-rings, gaskets, and diaphragms.

Chemraz® SD517 and SD625 seals for pharma offer:

  • Practically universal resistance to all Q3C Class 3 solvents
  • Minimal extractables in aqueous to nonpolar systems
  • Cleanroom production and packaging (SD517 only)
  • Very high thermal stability (up to 260°C)
  • Exceptionally long service lifetimes (orders of magnitude longer than silicone, EPDM, or Viton™)
  • Long-term stability in common sterilization, pyrogen inactivation, and prion-destroying conditions (SD625 only)

Chemraz® Elastomers for High-Performance Seals and Rubber Parts

Material Description Features
Chemraz® SD517 White Shore 80A
Perfluoro elastomer (FFKM)
• Near-universal chemical compatibility
• Suitable for continuous use up to 220°C/428°F
• ISO 7 Cleanroom Compounding, Molding & Packaging
• Complies with FDA, USP <87> and <88>, EU 1935/2004, and 3A standards
Chemraz® SD625 Black Shore 80A
Perfluoro elastomer (FFKM)
• Near-universal chemical compatibility
• Suitable for continuous use up to 260°C/428°F
• Complies with FDA, USP <87> and <88>, 3A

Visit our Resource Library for data sheets and other information about Chemraz® SD517 and Chemraz® SD625.

Medical Devices

Stainless steel is a core material for medical devices due to its strength, resilience, and compatibility with sterilizing conditions. However, stainless steel alloys are often unnecessarily heavy (up to 8.00 g / cm3) – increasing the risk of strain, injury, and life-threatening errors. In many cases, plastics are not strong enough to directly replace stainless steel alloys.

In radiography, the presence of any metal can make interpretation nearly impossible. The presence of metal artifacts on a diagnostic image can result in the difficult decision to expose a patient to further radiation in order to obtain better images.

Greene Tweed is one of the first companies to offer carbon fiber PEEK for surgical instruments. Our Orthtek® WF 50 percent carbon fiber PEEK composite has many advantages over metal and other plastics:

  • Very lightweight (1.54 g / cm3) to reduce strain and injury risk
  • Radiolucent to improve x-ray clarity and limit patient exposure
  • Comparable strength to metal
  • Successfully used as a structural material for insertion jigs, fixator rings, and other external medical devices
  • Available as complex geometries and assemblies in small custom batches (10s of units) or larger mass quantities (100,000s of units)

Orthtek® WF Carbon-Fiber PEEK for Metal Replacement

Material Description Features
Orthtek® WF Black 50% carbon fiber PEEK • Lightweight (1.54 g/cm^3)
• Comparable strength to metal
• Stable to repeated steam, EO, & gamma sterilization
• Highly radiolucent
• Available as small-batch plates (up to 1.5 in./38 mm) or low-cost, custom-molded parts

Visit our Resource Library for data sheets and other information about Orthtek® WF.

Analytical

Commercially successful analytical instruments must offer exceptional reliability under highly varied chemical, pressure, and temperature conditions. Customers expect their instruments to function perfectly for years, without preventative maintenance. Seals are a weak point in many HPLC and SEC instruments and in-process sensors. Frequent seal failure due to a design or material issue can frustrate the end-user and drive them to a competitor replacement.

When looking for a reliable alternative, Chemraz® 605 is a high-performance seal material with the near-universal compatibility of PTFE to all common HPLC solvents. Its excellent compression rate and extrusion resistance ensure long-term performance.

Greene Tweed offers Chemraz® 605 in standard parts, custom designs, or sheets. Our application engineers can assist in finding the best solution for your analytical product.

 

Chemraz® Elastomer for High-Performance Seals and Rubber Parts

Material Description Features
Chemraz® 605 Black Shore 80A • Near-universal chemical compatibility
• Suitable for continuous use up to 260°C/428°F

Visit our Resource Library for data sheets and other information about Chemraz® 605